Objective　　　 To determine the effects of probiotics on the hyperglycemia in patients with severe craniocerebral injury.　　　 Methods　　　 Forty patients who diagnosed as severe closed craniocerebral injury with Glasgow coma scale (GCS) from 5 to 8 over 12 h

admitted in Chongqing Emergency Medical Center from September 2011 to July 2012 were subjected in this study

and were randomized into observation group (n=18) and control group (

n

=22). The former was given probiotics solved into 20 mL warm water within 24 to 72 h following admission

while the later was treated only with 20 mL warm water. Other treatment was same to the 2 groups. Blood glucose were detected on days 0

4

7 and 15 after probiotics treatmen

t

GCS scores before and after treatment were also recorded.　　　 Results　　　 The observation group had no difference in blood glucose compared with control group before probiotics treatment (

P

0.05). But the level of blood glucose was significantly lower in the observation group than that control group on days 4

7 and 15 (

P

0.05). The observation group and control group both showed higher GCS scores than before intervention (

P

0.05)

but the score was significantly higher in observation group than that in control group after intervention (P0.05).　　　 Conclusion　　　The treatment of probiotics can relieve hyperglycemia in patients with severe craniocerebral injury.