Objective        To explore the association of polymorphism of signal transducer and activator of transcription-3 (STAT3) gene with the susceptibility of Kawasaki disease (KD) in Han children in Chongqing

  China.       Methods        The single nucleotide polymorphisms (SNPs) of STAT3 intron 11 (rs2293152C/G and rs957970C/T) in 130 patients with KD and 147 healthy controls were detected by sequence specific primers-polymerase chain reaction (SSP-PCR)

  and their statistical differences were analyzed.       Results        The frequency of homozygous CC genotype at rs2293152C/G in STAT3 of the KD patients were significantly higher than that of the controls (23.8% vs 10.2%

P=0.02). The frequency  of C allele at rs2293152C/C was higher in the KD patients than in the controls (45.4% vs 34.0%

P=0.006

OR=1.612

95%CI: 1.144 to 2.272). Meanwhile

  there was no statistical difference in the frequencies of allele and genotypes at rs957970C/T in STAT3 between the KD patients and controls (P0.05).       Conclusion        This study confirms the association between the STAT3 gene polymorphism at rs2293152 and the susceptibility of KD in Han children in Chongqing

  China. The children with rs2293152C allele are more vulnerable to KD

  and there is no significant association between polymorphism of rs957970 in STAT3 gene and the susceptibility of KD.