Objective       To investigate the mechanism of interferon-α/β (IFN-α/β) inhibiting lymphoma cell proliferation.       Methods       Lymphoma cells (Namalwa and JeKo-1) and leukemia cells (Jurkat and THP-1) were treated with IFN-α/β for 24 h. Cell viability was measured by CCK-8 assay. The mRNA and protein expression levels of SARI were detected by reverse transcription PCR

real-time PCR and Western blotting. The transcription factor binding sites in SARI gene promoter region were predicted using bioinformatics method.       Results       Lymphoma cells (Namalwa and JeKo-1) were effectively killed by both IFN-α and IFN-β (P0.05)

and the mRNA and protein expression levels of SARI were significantly up-regulated (P0.05). However

IFN-α/β had no significant effect on cell viability and SARI expression of leukemia cells (Jurkat and THP-1) (P0.05). Bioinformatics results revealed that transcription factor STAT might bind to SARI gene promoter region.       Conclusion       Upregulation of SARI

which is possibly mediated by STAT

may be involved in the process of IFN-α/β inhibiting lymphoma cell proliferation.