Objective　　　 To compare the overall effect of metabolic surgery on the body mass index (BMI) and metabolic indicators between obese and non-obese type 2 diabetes.　　　 Methods　　　 A total of 20 diabetic patients who undergoing metabolic surgery in our department from 2010 to 2012 were enrolled in this study. They were prospectively divided into obese diabetic group (BMI≥28 kg/m

2

n=10) and non-obese diabe

tic group (BMI28 kg/m

2

n=10) with BMI of 28 as cutoff point. Their pre-operative data were matched

and their BMI

glucose tolerance and insulin release

uric acid

total cholesterol

LDL cholesterol levels in 3 to 6 months after operation were recorded and compared to determine the different effect of the surgery.　　　 Results　　　 Correlation analysis showed that

the degree of decreased BMI after the operation had no relation with the pre-operative BMI in non-obese patients (r=0.416

P=0.232)

however

obvious correlation was found in obese patients between the decreased and pre-operative BMI (r=0.932

P0.001). In non-obese patients and obese patients before and after surgery

the total cholesterol levels and insulin resistance were significantly improved (P0.05)

and uric acid metabolism

low-density lipoprotein cholesterol levels did not change significantly. There was a significant difference in the decreased degree of BMI between the 2 groups

with obese patients more significant. There was no significant difference in improvement of total cholesterol levels and insulin resistance in the 2 groups.　　　 Conclusion　　　Metabolic surgery significantly improves the body weight

insulin resistance and blood lipids in obesity and non-obese diabetic patients. There is no difference in the improvement regardless of BMI is less than 28 or not. So

BMI more than 28 should not be the strict indication as the therapeutic surgery for diabetes.