Objective        To investigate  the possible causes of AIDS-related complex (HIV negative) in community population.       Methods        Qualitative systematic analysis was used to screen the cases with AIDS-related complex (HIV negative) that had been reported. The possible clustering types of the clinical features of AIDS-related complex were explored based on a cross-section study that had been conducted to observe the personality and clinical features of the cases with AIDS-relate

d complex.       Results        The qualitative systematic analysis suggested that the idiopathic CD4

+

T lymphocytopenia (ICL) and infection of nontuberculosis mycobacteria (NTM) had similar characteristics with AIDS-related complex (HIV negative). Through network investigation of 174 cases and field observation of 52 cases

the data showed that the AIDS-related complex population came from different areas of China

and was dominated by young and middle-aged male patients. The complained symptoms involved respiratory tract

gastrointestinal tract

skin

muscle

skeleton and nervous system. The clinical course could be divided into an acute period and a stable period. The special symptoms are swollen lymph nodes

snapping joint

osteodynia

muscle throbbing pain

skin nodules (rash)

greasy tongue coating and dry skin. The CD4

+

T lymphocytes 500/μL (32.69%)

the abnormal ratio of CD4/CD8 (30.77%)

the positive antibody of IFN-γ (36.69%) and positive PPD (++ to +++

75.00%) were detected in the 52 cases

and high risk sexual behavior was a suspected exposure factor.       Conclusion        The AIDS-related complex (HIV negative) in population can not be completely explained by mental disorder. The clinical features have obvious consistency and regularity

and need further study to verify.