Objective      To determine the effect of combined application of mecobalamine and citicoline to diabetic peripheral neuropathy.        Methods      A total of 120 patients with diabetic peripheral neuropathy admitted to our department from October 2010 to October 2011 were enrolled in this study. They were randomly assigned into 2 matched groups. All patients were given conventional therapy to reduce blood sugar

blood pressure and blood grease. The control group (n=60) was given mecobalamine

while the experimental group (n=60) received combinative application of mecobalamine and citicoline. After 3-month treatment as a course

the effective power and speed of nerve conduction were compared between pre- and post-treatment.        Results      There was significant decrease in HbA1c

systolic pressure

diastolic pressure

TG

TC

LDL-C in the 2 groups after treatment (P0.05)

but no difference was found between the 2 groups (P0.05). Symptoms as pain

numbness and hypoaesthesia were obviously attenuated in the 2 groups (P0.05)

and more significant effect was seen in the experimental group (P0.05). After the treatment

the velocity of motor nerve conduction was increased in the median nerve

common peroneal nerve

and tibial nerve in the 2 groups (P0.05)

but that of experimental group was increased more (P0.05).       Conclusion      Both mecobalamine and citicoline can validly attenuate symptoms of diabetic peripheral neuropathy and improve the velocity of motor nerve conduction. Synergic effect is found when the 2 agents are combined together.