<sup>1</sup>H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察

姚一搏; 许民辉; 徐伦山; 耿明英; 谭勇; 李飞鹏; 沈光建

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¹H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察

论著 | 更新时间：2026-01-09

- ¹H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察
- Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with ¹H-MRS guidance
- 陆军军医大学学报 2012年34卷第18期页码：1881-1883
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  中图分类号： R445.2;R817.5;R739.41
- 纸质出版：2012
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姚一搏,许民辉,徐伦山,耿明英,谭勇,李飞鹏,沈光建.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1881-1883.

　Yao Yibo,Xu Minhui,Xu Lunshan,Geng Mingying,Tan Yong,Li Feipeng,Shen Guangjian.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1881-1883.
姚一搏,许民辉,徐伦山,耿明英,谭勇,李飞鹏,沈光建.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1881-1883. DOI：

　Yao Yibo,Xu Minhui,Xu Lunshan,Geng Mingying,Tan Yong,Li Feipeng,Shen Guangjian.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1881-1883. DOI：

摘要

目的调查

H核磁共振波谱（

H-MRS）引导辅助伽玛刀治疗脑胶质瘤的效果。方法选择有明确病理诊断的脑胶质瘤20例，分为常规核磁共振（MRI）定位组和MRI结合核磁共振波谱（MRS）定位组，各10例。常规MRI定位组以肿瘤性增强病灶及周围短T

、长T

区为靶灶范围；MRI+MRS定位组则以肿瘤性增强病灶及周围短T

、长T

区间Cho:NAA指数（CNI）≥1.6者为靶灶范围。以伽玛刀治疗后12个月为终未观察期，统计分析两组治疗结果。结果治疗有效者13例（65%），包括常规MRI定位组6例，MRI+MRS定位组7例。10例（50%）患者发生脑水肿，包括常规MRI定位组8例，MRI+MRS定位组2例。统计分析示MRI+MRS定位组靶灶直径、脑水肿发生例数、脑水肿范围较常规MRI定位组明显下降（P0.05）。结论伽玛刀治疗加入MRS因素有助于对脑胶质瘤甄别，减少因盲目扩大治疗范围带来的并发症。

Abstract

Objective To investigate the effect of Gamma Knife treatment for glioma with

H-magnetic resonance spectroscopy (MRS) guidance. Method Twenty patients with glioma confirmed by pathological diagnosis were selected and divided into a conventional MRI positioning group and a MRI+MRS positioning group (n=10). The target area of the conventional MRI positioning group was defined as the tumorous-enhanced focus plus the surrounding short T

and long T

area

and that of the MRI+MRS positioning group was defi

ned as the tumorous-enhanced focus plus the Cho: NAA index (CNI)≥1.6 area in the surrounding short T

and long T

area. The differences of the treatment outcomes were statistically analyzed at 12 months after the Gamma Knife treatment. Results Thirteen (65%) of the 20 patients showed effective outcome

including 6 patients from the conventional MRI positioning group and 7 patients from the MRI+MRS positioning group. Brain edema was observed in 10 patients (50%)

including 8 patents from the conventional MRI positioning group and 2 patients from the MRI+MRS positioning group. The average maximum diameter of target area

the number of patients with brain edema and the range of brain edema decreased significantly in the MRI+MRS positioning group as compared with the conventional MRI positioning group (P0.05). Conclusion Gamma Knife treatment with

H-MRS guidance helps distinguish glioma

and can reduce the complications from the blind expansion of treatment area.

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1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察

Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance

DOI：

摘要

Abstract

关键词

Keywords

references

¹H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察

Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with ¹H-MRS guidance