Objective        To investigate the expression levels and clinical significance of X-linked inhibitor of apoptosis protein (XIAP) and c-jun in primary lung cancer tissues.       Methods       Immunohistochemical SP method was used to detect the expression levels of XIAP and c-jun in normal lung tissues

lung benign lesions

adjacent tissues of lung cancer and primary lung cancer tissues.       Results       The positive expression rates of XIAP and c-jun in the primary lung cancer tissues were significantly higher than those in the normal lung tissues

lung benign lesions and adjacent tissues of lung cancer (P0.05). The positive expression levels (MOD value) of XIAP and c-jun in advanced lung cancer tissues (Stage Ⅲ and Ⅳ) were significantly higher than those in the early-stage lung cancer tissues (Stage Ⅰ and Ⅱ) (P0.05). The  positive expression levels of XIAP and c-jun in the lung cancer tissues with lymph node metastasis were significantly higher than those in the lung cancer tissues without lymph node metastasis (P0.05). The positive expression levels (MOD value) of XIAP and c-jun were positively correlated in the lung cancer tissues (r=0.232，P0.05). The positive expression levels of XIAP and c-jun in the patients with postoperative survival time less than 1 year were significantly higher than those in the patients with postoperative survival time more than 1 year (P0.05). The positive expression levels (MOD value) of XIAP and c-jun were not correlated with patients’ age

sex

tumor diameter or histopathological type (P0.05).       Conclusion       High expression of XIAP and c-jun indicates poor prognosis of patients with lung cancer. XIAP and c-jun expression levels can be used as reference indices for clinical diagnosis and prognosis prediction in patients with lung cancer.