Objective      To study the correlation of cerebral deep medullary vein (DMV) characteristics and changes in internal jugular vein (IJV) with multiple sclerosis (MS).       Methods      Thir

ty recurrent remittent MS patients (MS group) and 30 age- and sex-matched controls (control group) underwent conventional magnetic resonance imaging (MRI)

3-dimensional (3-D) enhanced T

2

*

-weighted angiography (ESWAN)

and 3-D time-resolved imaging of contrast kinetics (TRICK). Changes in periventricular DMV of MS group and control group were observed on 3-D ESWAN and scored.       Results      The periventricular DMV score was  significantly lower in MS group than in control group (1.67±0.25 vs 3.00±0.00

P0.01). The course of MS was ＞2.0 years in 16 patients with 1 score and 0.5- 2.0 years in 8 patients with 2 scores (P0.01)

and ＜0.5 year in 6 patients (P0.05). Dilated and prolonged penetrating veins were found in 9 chronic MS lesions. IJV stenosis was observed in 5 (16.7%) MS patients and 2 (6.7%) controls

respectively (P0.05). The IJV stenosis was not significantly correlated with the reduced DMV (P0.05). The reduced and shortened DMV were positively correlated with the course of MS (r=－0.89

P0.01) but negatively correlated with the expanded disability status scale (EDSS) score (r= 0.05

P0.05). The IJV stenosis was not significantly correlated with the EDSS score and the course of MS (Z=0.20

P0.05; Z=3.46

P0.05).       Conclusion      Changes of periventricular DMV are not significantly correlated with IJV stenosis in MS patients.