Objective       To investigate the related factors of hemorrhagic transformation after acute ischemic stroke in order to provide evidence of preventing HT

guiding clinical treatment

and improving the prognosis.       Methods       A total of 120 acute ischemic stroke subjects hospitalized in our department from March 2011 to January 2012 were included in the study. Sixty-nine patients occurred hemorrhagic transformation identified by cranial CT

routine MRI or SWI scanning. The correlation of HT with related factors was analyzed with univariate analysis and logistic regression analysis.       Results       In univariate analysis

the HT incidence were significantly higher in the groups of patients with large infarct size

hypertension

diabetes mellitus

coronary heart disease

albuminuria

not taking preventive anti-platelet aggregative and anticoagulant agents before stroke

low LDL-c level

low PLT

and high NIHSS score at admission （P0.05，P0.01）. It showed that only NIHSS score at admission were significantly correlated with HT by Logistic regression analysis （OR=1.702，95%CI：1.198 to 2.417，P=0.003）. There was significant difference in NIHSS score in HT and non-HT groups at admission (35.06 vs 23.90，P0.05)

and the former group showed more severe nervous injury. There was no significant difference in NIHSS score in HT group at admission and discharged (P0.05)

but difference was found in non-HT group at the 2 time points (P0.05). Non-HT group had decreased score at discharged and better prognosis.       Conclusion       Risk factors of HT include large infarct size

not taking preventive anti-platelet aggregation or anti-coagulation agents before stroke

hypertension

diabetes mellitus

coronary heart disease

albuminuria

low LDL-c level

low PLT and high NIHSS score at admission. HT has poor clinical outcome and poor prognosis.