IL-4、IFN-γ及LTE<sub>4</sub>浓度在婴幼儿喘息性疾病中的变化及其意义

颜婷; 孙萍; 陈婷婷; 王倩; 黄正刚

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IL-4、IFN-γ及LTE₄浓度在婴幼儿喘息性疾病中的变化及其意义

论著 | 更新时间：2026-01-09

- IL-4、IFN-γ及LTE₄浓度在婴幼儿喘息性疾病中的变化及其意义
- Change and significance of serum IL-4 and IFN-γ and urinary leukotriene E4 in infants with asthmatic diseases
- 陆军军医大学学报 2012年34卷第18期页码：1873-1876
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  中图分类号： R392.11;R392.3;R725.6
- 纸质出版：2012
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颜婷,孙萍,陈婷婷,王倩,黄正刚.IL-4、IFN-γ及LTE4浓度在婴幼儿喘息性疾病中的变化及其意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1873-1876.

　Yan Ting,Sun Ping,Chen Tingting,Wang Qian,Huang Zhenggang.Change and significance of serum IL-4 and IFN-γ and urinary leukotriene E4 in infants with asthmatic diseases[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1873-1876.
颜婷,孙萍,陈婷婷,王倩,黄正刚.IL-4、IFN-γ及LTE4浓度在婴幼儿喘息性疾病中的变化及其意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1873-1876. DOI：

　Yan Ting,Sun Ping,Chen Tingting,Wang Qian,Huang Zhenggang.Change and significance of serum IL-4 and IFN-γ and urinary leukotriene E4 in infants with asthmatic diseases[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1873-1876. DOI：

摘要

目的探讨患喘息性疾病的婴幼儿血清白介素-4（IL-4）、干扰素-γ（IFN-γ）及尿白三烯E

（LTE

）浓度的变化及其意义。方法采用竞争性酶联免疫吸附法（ELISA）检测22例急性期、恢复期喘息性疾病患儿（喘息组），20例急性期非喘息的下呼吸道感染患儿（非喘息组），20例健康体检儿（正常对照组）血清IL-4、IFN-γ及尿LTE

水平，分析IL-4与IFN-γ的比值，分析IL-4、IFN-γ与尿LTE

的相关性。结果喘息组急性期血清IL-4水平较非喘息组急性期及正常对照组均明显升高（P0.05，0.01）；血清IFN-γ水平明显降低(P0.01)；尿LTE

水平较正常对照组明显升高(P0.01)，但与非喘息组急性期比较差异无统计学意义（P0.05）；喘息组恢复期血清IL-4水平较急性期明显下降(P0.01)，但仍高于正常对照组(P0.01)；血清IFN-γ水平明显升高(P0.01)，但仍低于正常对照组(P0.01)；尿LTE

水平明显降低(P0.01)，但仍高于正常对照组(P0.01)。喘息组急性期血清IL-4/IFN-γ比值较非喘息组急性期及正常对照组均明显升高（F=15.86，P0.01）；恢复期血清IL-4/IFN-γ比值较急性期明显下降(t=4.14，P0.01)，但仍高于正常对照组，且有统计学差异(t=5.94，P0.01)。喘息组急性期尿LTE

水平与血清IL-4水平呈正相关（r=0.82，P0.01），与血清IFN-γ水平呈负相关（r=-0.81，P0.01）。结论 IL-4、IFN-γ及LTE

可能共同参与婴幼儿喘息性疾病的气道炎症反应，喘息患儿存在Th1/Th2免疫失衡。

Abstract

Objective To investigate the changes in serum levels of interleukin-4 (IL-4)

interferon-γ（IFN-γ）and urinary level of leukotriene E

(LTE

) in infants with asthmatic diseases and their significances.

Methods Serum levels of IL-4 and IFN-γ and urinary levels of LTE

were measured by competitive ELISA in 22 infants with acute and convalescence asthmatic diseases (asthmatic group)

20 infants with acute non-asthmatic diseases but with respiratory tract infection (non-asthmatic group)

and 20 healthy infants (normal control group). The ratio of IL-4 to IFN-γ and the correlations between urinary LTE

and serum IL-4

and between urinary LTE

and serum IFN-γ were analyzed. Results The serum levels of IL-4 in acute asthma period was obviously higher than that of acute non-asthma and normal control（P0.05

0.01）. The serum levels of IFN-γ in acute asthma period was significantly lower than those of acute non-asthma and normal control（P0.01）. The urinary levels of LTE

in acute asthma period was higher than normal control group（P0.01）

but were not significantly different from acute non-asthma （P0.05）. In remission/convalescence

the serum levels of IL-4 were lower than those of acute period (P0.01)

but were still higher than normal control group (P0.01). The serum levels of IFN-γ were higher than those of acute period (P0.01)

but were still lower than normal control group (P0.01). The urinary levels of LTE

were obviously lower than those of acute period (P0.01)

but were still higher than normal control (P0.01). The ratio of IL-4 to IFN-γ in acute asthma period was higher than that of acute non-asthma and normal control group（F=15.86，P0.01）.In remission

the ratio of IL-4 to IFN-γ was lower than that in acute period (t=4.14

P0.01)

but was still higher than normal control group (P0.01). There was positively correlation between urinary LTE

and serum IL-4 levels in the acute stage in asthmatic group（r=0.82

P0.01）. There was negative correlation between urinary LTE

and serum IFN-γ levels in the acute stage in asthmatic group（r=-0.81

P0.01). Conclusion IL-4

IFN-γ and LTE

may all be involved in th

e pathogenesis of respiratory tract inflammation in infant with asthmatic diseases. There are immune imbalance of Th1/Th2 in infant with wheezing.

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IL-4、IFN-γ及LTE4浓度在婴幼儿喘息性疾病中的变化及其意义

Change and significance of serum IL-4 and IFN-γ and urinary leukotriene E4 in infants with asthmatic diseases

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摘要

Abstract

关键词

Keywords

references

IL-4、IFN-γ及LTE₄浓度在婴幼儿喘息性疾病中的变化及其意义