Objective      To evaluate the therapeutic effect of endoscopic submucosal dissection (ESD) for 41 cases suffering from colorectal laterally spreading tumor (CLST).       Methods      A retrospective study was performed in 41 CLST cases who operated with ESD in our endoscopic center from May 2009 to March 2012. Procedure time

tumor diameter

en bloc resection rate

residue rate

recurrent rate

cure rate and associated complications after ESD were evaluated.       Results      Among the 41 CLST cases receiving ESD

procedure time ranged from 10 to 115 min (mean 63.2±24.3)

lesions diameter from 1.2 to 12 cm (mean 4.0±2.7)

and en bloc rate was 92.3% (38/41)

intraoperative perforation 2.4% (1/41)

postoperative perforation 2.4% (1/41)

postoperative bleeding 4.8% (2/41)

postoperative rectum stricture 2.4% (1/41)

and residue rate 2.4% (1/41). During the follow-up of 1 to 34 month (mean 12.0±9.7)

recurrent rate was 4.9% (2/41)

and cure rate was 95.1% (39/41).       Conclusion      ESD has a good therapeutic effect for CLST

with short procedure time

high en bloc resection and low recurrent rate.