2009-2011年重庆某三甲医院铜绿假单胞菌耐药性分析

杨政; 袁喆; 李崇智; 任玉涵

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2009-2011年重庆某三甲医院铜绿假单胞菌耐药性分析

论著 | 更新时间：2026-01-09

- 2009-2011年重庆某三甲医院铜绿假单胞菌耐药性分析
- Resistance surveillance of Pseudomonas aeruginosa in a chongqing Grade AAA hospital from 2009 to 2011
- 陆军军医大学学报 2012年34卷第21期页码：2191-2194
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  中图分类号： R378.99+1;R181.35;R915
- 纸质出版：2012
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杨政,袁喆,李崇智,任玉涵.2009-2011年重庆某三甲医院铜绿假单胞菌耐药性分析[J].陆军军医大学学报(原第三军医大学学报),2012,34(21):2191-2194.

　Yang Zheng,Yuan Zhe,Li Chongzhi,Ren Yuhan.Resistance surveillance of Pseudomonas aeruginosa in a chongqing Grade AAA hospital from 2009 to 2011[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(21):2191-2194.
杨政,袁喆,李崇智,任玉涵.2009-2011年重庆某三甲医院铜绿假单胞菌耐药性分析[J].陆军军医大学学报(原第三军医大学学报),2012,34(21):2191-2194. DOI：

　Yang Zheng,Yuan Zhe,Li Chongzhi,Ren Yuhan.Resistance surveillance of Pseudomonas aeruginosa in a chongqing Grade AAA hospital from 2009 to 2011[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(21):2191-2194. DOI：

摘要

目的分析重庆医科大学附属第一医院2009年1月至2011年12月分离的铜绿假单胞菌对抗菌药物的耐药性，为临床合理治疗提供依据。方法采用纸片扩散法，以CLSI2010年标准判断临床分离株的敏感性，分析采用WHONET5.4及SPSS 18.0统计软件。结果 3年来共分离出铜绿假单胞菌853株，其中多重耐药铜绿假单胞菌165株，占19.3%。2011年较2009年，分离出的铜绿假单胞菌对阿米卡星、头孢他啶、头孢哌酮、环丙沙星的耐药率分别由17.8%、25.8%、77.9%、28.2%下降至11.9%、12.8%、25.9%、23.1%；对亚胺培南、β-内酰胺酶抑制剂复合物的耐药率分别由2009年的14.7%、5.3%～11.7%上升至2011年的22.5%、12.2%～14.4%。ICU多重耐药铜绿假单胞菌的检出率明显高于非ICU，且其在ICU与非ICU的检出率均有下降。多重耐药铜绿假单胞菌对头孢他啶、头孢吡肟、头孢哌酮耐药率分别由2009年的61.9%、57.1%、100%下降至2011年的39.0%、51.2%、70.7%；对亚胺培南、β-内酰胺酶抑制剂复合物的耐药率分别从2009年的33.3%、33.3%～35.7%上升至2011年的58.5%、43.9%～46.3%。结论该三甲医院多重耐药铜绿假单胞菌对亚胺培南和β-内酰胺酶抑制剂复合物的耐药率，2011年较2009年明显上升，加强细菌耐药性监测和抗菌药物分级管理，以利于指导临床合理使用抗菌药物及减少和控制细菌耐药的发生。

Abstract

Objective To investigate the drug resistance of clinical isolates of P. aeruginosa from Jan. 2009 to Dec. 2011

and provide a reference for clinical treatment. Methods Disk diffusion test was used to study the antimicrobial susceptibility. Results were evaluated on the basis of CLSI 2010. WHONET 5.4 and SPSS l 8.0 were used to analyze the data. Results During the past 3 years

835 strains of P. aeruginosa were separated from all kinds of clinical samples

including 165 strains of multiple drug-resistant P. aeruginosa

which accounted for 19.3%. The resistance rates of the isolated strains of P. aeruginosa to amikacin

ceftazidime

cefoperazone

ciprofloxacin was decreased from 17.8%

25.8%

77.9%

and 28.2% in 2009 to 11.9%

12.8%

25.9%

and 23.1% in 2011

respectively. And its resistance rates to imipenem

beta-lactamase inhibitors composite was increased from 14.7%

5.3% to 11.7% in 2009 to 22.5%

12.2% to 14.4% in 2011. The detection rate of multiple drug-resistant P. aeruginosa in the ICU was found significantly higher than that in the non-ICU

and the isolated strains of multiple drug-resistant P. aeruginosa

both from ICU and non-ICU

their detection rates were decreased. Compared with the resistance rates of multiple drug-resistant P. aeruginosa to ceftazidime

cefepime and cefoperazone in 2009

the resistance rates in 2011 were reduced from 61.9%

57.1%

and 100% to 39.0%

51.2%

and 70.7%

respectively. And the resistance rates to imipenem

beta-lactamase inhibitors composite in 2011 rose from 33.3%

33.3% to 35.7% in 2009 to 58.5%

43.9% to 46.3%

respectively. Conclusion The resistance rates of drug-resistant P. aeruginosa in our hospital to imipenem and beta-lactamase inhibitors composite are significantly higher in 2011 than in 2009. The monitoring of antibiotic resistance and the management of antibactics grading system should be strengthened

so as to help guide the rational use of antimicrobials clinically

reduce and control the occurrence of bacterial resistance.

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