Objective        To study the effect of hypertonic sodium chloride hydroxyethyl starch 40（HHS）on resuscitation of rats

following uncontrolled hemorrhagic shock (UHS).       Methods       A rat UHS model was established with the modified Capone method. Thirty SD rats were randomly divided into normal control (NC) group

normal saline (NS) group

and HHS group (10 in each group). The blood pressure in NS and HHS groups was decreased to 40 mmHg by artery bloodletting

and then active hemorrhage was induced by cutting the tail at 1/4 from its end. The animals were given NS and HHS infusion to maintain their MAP at 50 mmHg. One hour after resuscitation

the animals underwent operation for hemostasis followed by blood and sufficient fluid transfusion to maintain their MAP at 90 mmHg. Two hours after resuscitation

the rats were replaced in cages. Their heart rate (HR)

pH value

BE

LAC

PaO

2

PT

APTT

CKMB

ALT

Cr

blood loss

fluid transfusion

and survival rate were measured at 0

30

90 and 210 min after UHS

respectively.       Results       The HR was significantly higher in HHS group and NS group after resuscitation than after HHS (P0.05). The pH value

BE (mmol/L) and PaO

2

  were significantly higher and the LAC level was significantly lower whereas the PT and APTT were significantly shorter in HHS group than in NS group after resuscitation (P0.05). The serum levels of CKMB

ALT

AST and Cr were significantly lower in HHS group than in NS group after resuscitation (P0.05). The active hemorrhage and fluid transfusion volume were significantly less whereas the 24 and 72 h survival rates were significantly higher in HHS group than in NS group (P0.05）.       Conclusion        The effect of HHS is rather good on resuscitation of rats following UHS.