Objective      To explore the changes of the regional homogeneity of resting-state brain activity in patients with posttraumatic stress disorder (PTSD).       Methods      Resting-state functional magnetic resonance imaging (fMRI) was performed in 9 PTSD patients (PTSD group) and 15 healthy participants (normal control group). The regional homogeneity (ReHo) values of resting-state brain activity in all the subjects were calculated by DPARSF software. One and two sample t-test was used to observe the changes of the ReHo values between the two groups.       Results      The results of the one-sample t-test showed that the ReHo values of the PTSD group and the normal control group increased in the default mode network

including prefrontal lobe and posterior cingulate gyrus (P0.05

cluster50). The results of the two-sample t-test showed that the ReHo values of the PTSD group increased in the right superior occipital gyrus

left middle occipital gyrus

left precuneus and left insula

but decreased in the right supramarginal gyrus and left inferior frontal gyrus (P0.05

cluster50).       Conclusion      The changes of the regional homogeneity of resting-state brain activity in patients with PTSD may relate with the dysfunction of the emotion and memory processing of the brain.