Syncytin和GCMa在特发性胎儿生长受限胎盘中的表达

韩笑; 崔世红; 张婷; 张林东; 程国梅; 赵岚岚

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Syncytin和GCMa在特发性胎儿生长受限胎盘中的表达

论著 | 更新时间：2026-01-09

- Syncytin和GCMa在特发性胎儿生长受限胎盘中的表达
- Expression of syncytin and glial cells missing in idiopathic fetal growth restriction placenta
- 陆军军医大学学报 2012年34卷第19期页码：1949-1952
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  中图分类号： R394.3;R446.8;R714.56
- 纸质出版：2012
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韩笑,崔世红,张婷,张林东,程国梅,赵岚岚.Syncytin和GCMa在特发性胎儿生长受限胎盘中的表达[J].陆军军医大学学报(原第三军医大学学报),2012,34(19):1949-1952.

　Han Xiao,Cui Shihong,Zhang Ting,Zhang Lindong,Cheng Guomei,Zhao Lanlan.Expression of syncytin and glial cells missing in idiopathic fetal growth restriction placenta[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(19):1949-1952.
韩笑,崔世红,张婷,张林东,程国梅,赵岚岚.Syncytin和GCMa在特发性胎儿生长受限胎盘中的表达[J].陆军军医大学学报(原第三军医大学学报),2012,34(19):1949-1952. DOI：

　Han Xiao,Cui Shihong,Zhang Ting,Zhang Lindong,Cheng Guomei,Zhao Lanlan.Expression of syncytin and glial cells missing in idiopathic fetal growth restriction placenta[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(19):1949-1952. DOI：

摘要

目的探讨Syncytin及glial cells missing（GCMa）在特发性胎儿生长受限（idiopathic fetal growth restriction，IFGR）患者胎盘组织中的表达及意义。方法选取剖宫产分娩的IFGR孕妇32例为研究组，同期因社会因素剖宫产分娩的健康足月孕妇30例作为健康对照组。采用免疫组化S-P法和逆转录聚合酶链反应（RT-PCR）检测2组胎盘组织中Syncytin 和GCMa的表达。结果免疫组化及RT-PCR结果均显示Syncytin和GCMa在研究组胎盘组织中表达水平低于健康对照组，差异均具有显著统计学意义（P0.01）。Syncytin及GCMa在研究组胎盘组织中表达均降低，两者呈正相关（r=0.537，P0.05）。结论 Syncytin与GCMa在IFGR胎盘组织中均低表达，提示可能在该疾病的发生、发展过程中起重要作用。

Abstract

Objective To study the expression of syncytin and glial cells missing (GCMa) in idiopathic fetal growth restriction (IFGR) placenta. Methods Thirty-two pregnant women who underwent cesarean delivery due to IFGR placenta served as an experimental group and 30 normal full-term pregnant women who underwent cesarean delivery due to social factors served as a control group in this study. Expressions of syncytin and GCMa in IFGR placenta tissue samples from two groups were detected by immunohistochemistry (IHC) and RT-PCR

respectively. Results IHC and RT-PCR showed that the expression levels of syncytin and GCMa were significantly lower in experimental group than in control group (P0.01). The low expression levels of syncytin and GCMa in experimental group were positively correlated with each other（r=0.537，P0.05）. Conclusion The syncytin and GCMa expressions are down-regulated in IFGR placenta tissue

indicating that they play an important role in the occurrence and progress of IFGR placenta.

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