Objective      To explore the potential relationship between the level of IL-6 in the serum and cerebrospinal fluid (CSF) and epileptogenesis of pediatric intractable epilepsy.       Methods      Using the ELISA method to detect the changes of IL-6 content in 48 cases of pediatric intractable epilepsy seizures in the serum and cerebrospinal fluid.       Results      The IL-6 level in serum was 8.23±0.58 pg/ml and 11.63±1.35 pg/ml in 1 h and 6 h after seizure

respectively

which was significantly different with controls (0.75±0.48 pg/ml，1 h: P0.05; 6 h: P0.01) . In addition

The IL-6 level in serum was 10.35±3.06 pg/ml and 19.55±2.32 pg/ml in 1 h and 6 h after seizure

respectively

which was also significantly increased compared with controls (1.27±0.65 pg/ml，P0.01). However

the IL-6 levels in serum and CSF 12 h after seizure were tendency towards the baseline.       Conclusion      The seizure induced an increase of IL-6 levels in serum and CSF

which may exacerbate the injury caused by inflammation

would be involved in the epileptogenesis of pediatric intractable epilepsy.