Objective        To explore the correlation of tumor markers with lung function in rheumatoid arthritis (RA) accompanied with interstitial lung diseases.       Methods       Eighty-two RA inpatients in our hospital from

January 2009 to January 2011 were recruited in this study. Among these RA patients

38 were accompanied with interstitial lung diseases

and the left 44 were not. Tumor markers

such as CEA

CA15-3

CA19-9

and pulmonary function indexes

including forced expiratory volume (FVC)

first second forced expiratory volume (FEV

1

)

carbon monoxide diffusion capacity (DL

CO

)

and anti-CCP antibody were detected in all of patients. Correlation between the expression of these markers and pulmonary function indexes

level of anti-CCP antibody was analyzed by Spearman Rank Correlation.       Results      Serum levels of CEA

CA15-3 and CA19-9 were significantly higher in RA-ILD group than in RA group ( P0.01). The percentage of predicted value for FVC

FEV

1

and DL

CO

was significantly lower in RA-ILD group than in RA group (P0.01). There was no significant difference between two groups in anti-CCP level (P0.05). Serum CEA level was inversely correlated with FVC( r=－0.499

P0.0l)

FEV

1

( r=－0.576

P0.01) and DL

CO

(r=－0.512

P0.01) in RA-ILD patients. There was no correlation between serum level of CEA

CA15-3 and CA19-9 and anti-CCP antibody in RA-ILD patients ( r=－0.192

－0.264

－0.268，respectively

P0.05).       Conclusion        The expression of tumor markers

including CEA

CA15-3 and CA19-9 is increased in RA-ILD. CEA level may reflect the degree of lung function impairment in RA-ILD

but have no relation with the joint lesion severity.