Objective        To prepare the indirubin solid dispersion with polyvinyplyrrolidone (PVP

K30

) in order to improve the dissolution of indirubin.        Methods        The solid dispersion containing indirubin was prepared with PVP

K30

as carrier (1∶9) by solvent evaporation. The status of indirubin existence in the dispersion form was studied by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC).  Indirubin from the solid dispersion was determined to evaluate the dissolution property after being prepared as solid dispersion.       Results        SEM and DSC results showed that indirubin was distributed in solid dispersion as an amorphous state. The dissolution percentage of indirubin was significant

ly higher in solid dispersion (36.93%) when compared with those as indirubin power (4.81%) and physical mixture (11.42%).        Conclusion      Our prepared PVP

K30

solid dispersion containing indirubin has indirubin changed its dispersedness with higher dissolution.