Objective      To evaluate and compare the clinical therapy efficacy of focused ultrasound and laser coagulation in the treatment of cervical intraepithelial neoplasia (CIN) Ⅰ with high-risk subtypes of HPV infection.       Methods      A total of 618 cases of CIN Ⅰwith high-risk types of HPV infection who were treated in our department from April 2006 to April 2010 were prospectively randomized into focused ultrasound group (n=320) and laser power coagulation group (n=298). The effectiveness and safety were evaluated by biopsy and HPV detection before and in 6 months after treatment. Follow-up were carried out in 2

6 and 12 months after treatment.       Results      There was no significant difference in blood loss between the 2 groups. Postoperative vaginal bleeding and vaginal fluid were significantly lesser in focused ultrasound than in laser coagulation group (P0.05). In the first 6 months after treatment

among the 300 cases with follow-up out of focused ultrasound group

there were  292 cases of CIN Ⅰ subsided

with a cure rate of 97.3%. And 200 cases had high-risk types of HPV entire negative

with a clearance rate of 66.7%

and 40 cases were partial negative

with an effective rate of 80%. Among the 290 cases of laser coagulation who were followed up

CIN Ⅰ cured in 280 cases

with a cure rate of 96.6%; 185 cases of high-risk types of HPV infection were entire negative

with a clearance rate of 63.8%

and 30 cases were in the partial negative

with an effective rate of 74.1%. There was no significant difference in the cure rate of CIN Ⅰ and the clearance rate of HPV between the 2 groups. Significant correlation was found between the regression of CIN Ⅰand the clearance of HPV in the 2 groups (P0.05

r=0.175 9 for focused ultrasound group and 0.147 3 for laser coagulation group).       Conclusion      In the clearance of high-risk HPV types and CINⅠ

the effectiveness of focused ultrasound treatment and laser coagulation treatment are very significant and have no significant difference

but the later has less colporrhagia and vaginal discharge after treatment.