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纸质出版:2012
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王一丞,张一鸣,石小花,杨芷,王韶亮,樊东力.仿生化硅橡胶基羟基磷灰石涂层材料的研制与性能检测[J].陆军军医大学学报(原第三军医大学学报),2012,34(04):324-327.
Wang Yicheng,Zhang Yiming,Shi Xiaohua,Yang Zhi,Wang Shaoliang,Fan Dongli.Preparation and evaluation of a new biomimetic material-silicone rubber coated by hydroxyapatite[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(04):324-327.
王一丞,张一鸣,石小花,杨芷,王韶亮,樊东力.仿生化硅橡胶基羟基磷灰石涂层材料的研制与性能检测[J].陆军军医大学学报(原第三军医大学学报),2012,34(04):324-327. DOI:
Wang Yicheng,Zhang Yiming,Shi Xiaohua,Yang Zhi,Wang Shaoliang,Fan Dongli.Preparation and evaluation of a new biomimetic material-silicone rubber coated by hydroxyapatite[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(04):324-327. DOI:
目的 制作硅橡胶基羟基磷灰石涂层材料并优化其技术参数,并对涂层材料进行形貌观察和理化性能检测。 方法 将粉末状羟基磷灰石(HA-1,粒径40 μm)和颗粒状羟基磷灰石(HA-2,粒径150 μm)喷涂于硅橡胶(Silicon rubber,SR)表面,制备出两种涂层材料(HA-1/SR)和(HA-2/SR),使用万能材料试验机检测材料生物力学性能,并采用扫描电镜(scanning electron microscope,SEM)、傅立叶红外光谱(Fourier transform infrared spectrometer,FTIR)、X射线光电子能谱(X-ray photoelectron spectroscopy,XPS)技术对材料的表面性能进行检测,将所得数据用SPSS 13.0进行统计学分析。 结果 SEM观察见HA均匀涂布在SR表面,粘着紧密;FTIR和XPS检测结果表明:HA与SR属于物理性结合,未破坏两者的化学结构;在理化性能检测中,HA/SR的邵氏硬度、抗拉强度、断裂伸长率与SR相比明显降低(P<0.05),但符合临床应用要求。 结论 HA/SR涂层材料的理化性能满足临床使用要求,且HA分布于材料表面会使其具有良好的生物相容性,可望作为一种理想的软组织填充材料。
Objective To prepare a new biomimetic material-silicone rubber coated by hydroxyapatite (HA/SR) and optimize the technique parameters
as well as to evaluate its topography and physicochemical properties. Methods Silicon rubber was coated by HA powder (HA-1
particle diameter 40 μm) and HA particles (HA-2
particle diameter 150 μm), which were named HA-1/SR and HA-2/SR. The mechanical properties were evaluated by an electronic universal material testing instrument. The Scanning electron microscopy (SEM)
Fourier transform infrared spectrometry (FTIR) and X-ray photoelectron spectroscopy (XPS)were used to analyze the material surface properties. Results Hydroxyapatite was uniformly coated on the surface of SR. Using SEM we found that HA and SR attached tightly. FTIR and XPS illustrated that the physically binding did not destroy the chemical constitution of HA and SR. Even the Shore hardness
tensile strength
and elongation at break of HA/SR were significantly decrease compared with SR (P<0.05)
HA/SR still can meet the clinical demand. Conclusion Although some physical properties are significantly changed
HA/SR can still meet clinical demands. In addition
HA/SR may be more suitable as a soft-tissue implant than SR and has the potential to be used in plastic surgery as HA has good biocompatibility.
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