Objective        To determine the efficiency of Shuangge Jiecheng Pill on the treatment of alcoholic fatty liver in the rat model.       Methods        A total of 65 SD rats were randomly divided into normal control group (n=11) and model group (n=54). The rat model of alcoholic fatty liver disease was induced by Chinese liquor (56% Hongxing wine) by intragastric administration. One rat from normal control and 4 from the model group were used for model identification. The rest 50 rats of model group were further divided into Haiwang group (HW group

n=10

gastrically treated by Haiwang Jinzun Pill at 1.5 g/(kg·d)

twice per day for 4 weeks)

and high-

middle- and low-dosed Shuangge Jiecheng Pill groups [HD

MD

and LD groups

treated with the pill at 20

10 and 5 g/（kg·d）

treated as HW group]. At the end of treatment

all rats were killed and their liver was taken for pathological changes. The serum levels of TNF-α

IL-6

leptin (LEP)

adiponectin (ADP) and free fatty acid (FFA) in the rats of all groups were measured and compared.       Results        High-dosed Shuangge Jiecheng Pill resulted in obvious decrease in serum levels of IL-6[(62.49±34.16)pg/ml]

TNF-α [(3.25±0.20)ng/ml]

FFA [(572.16±45.37)μmol/L] and LEP [（1.89±0.21）ng/ml] when compared with those of normal control and HW group (P0.01)

and significant increase in ADP [（3.05±0.27）mg/ml] compared with that of normal control[（2.17±0.37）mg/ml] and HW group[（2.69±0.32）mg/ml，P0.01]. Pathological observation displayed obvious improvement in liver fatty changes and infliammation in Shuangge Jiecheng Pill treatment groups.       Conclusion        Shuangge Jiecheng Pill exerts curative effect on alcoholic fatty liver disease in rats.