Objective      To evaluate the role of miniprobe endoscopic ultrasonography combined with CT examination in diagnosis and treatment of large gastric submucosal tumors (SMT).       Methods      Fifty-two cases of SMT with ultrasound cross-section diameter not less than 20 mm detected by miniprobe endoscopic ultrasonography combined with abdominal 64-slice CT examination were collected to determine the location of tumor invasion

depth

origin and surrounding and distant organ metastasis. The gastric submucosal tumors growing in gastric lumen without involving gastric serosa were treated with endoscopic submucosal dissection (ESD). The tumors invading gastric serosa and growing to the outside of gastric lumen were treated with laparoscopy or laparotomy. All the resected specimens were sent to routine pathological examination and immunohistochemistry. All the patients were followed up by gastroscopy and CT after six months. The role of miniprobe endoscopic ultrasonography combined with CT examination in the diagnosis and treatment of large gastric SMT was evaluated based on the efficacy.       Results      There were 20 cases of benign stromal tumor

16 cases of malignant stromal tumor

5 cases of leiomyoma

6 cases of ectopic pancreas and 5 cases of lipoma. CT examination showed 30 cases of gastric submucosal tumors growing in gastric lumen without gastric serosa involvement and surrounding organ metastasis

which were treated with ESD. In the 30 cases

2 cases of gastric perforation were observed and were treated by titanium clipping and conservative treatment. The remaining 22 cases were treated with laparoscopy or laparotomy. After 3 months

all the lesions healed without recurrence.       Conclusion      Miniprobe endoscopic ultrasonography combined with CT examination in diagnosis of large gastric SMT can obtain accurate pathological condition

which is important for selecting therapeutic regimens for large gastric SMT.