Objective      To investigate whether a single loading of 80 mg atorvastatin before receiving percutaneous coronary intervention (PCI) can reduce postoperative inflammation

platelet activity and incidence of major adverse cardiac events (MACE) in stable angina patients who had accepted a long-term statin therapy.       Methods      One hundred and fifteen patients with chronic stable angina who underwent PCI in our department from Jan. 2010 to Jul. 2011 were prospectively selected. The patients were divided into the intensive statin group (a single loading of 80 mg atorvastatin in 12 h before receiving PCI) and the standard group (a routine dosage of 20 mg atorvastatin at same time point). Serum levels of interleukin-6 (IL-6)，high sensitivity C-reactive protein（hs-CRP）

tumor necrosis factor-α (TNF-α)

GMP140 and p-selectin (CD62p) were measured in 24 h before and 24 h after PCI in all patients. The incidence of MACE was observed in 30 d after surgery.       Results      The basic clinical data and PCI basic characteristics between the two groups showed no obvious difference（P0.05）. When compared with those in the standard group

the levels of inflammation and platelet activation factors were lower in the intensive statin group after 24 h（P0.05）. The levels of inflammation and platelet activation factors at 24 h after PCI were lower than before PCI in the intensive statin group （P0.05）. While the levels of inflammation and platelet activation factors at 24 h after PCI showed a rising trend than before PCI in the standard group（P0.05）. The incidence of MACE in the intensive group was lower than that in the standard group（P0.05）.       Conclusion      Before receiving PCI

a single loading of 80 mg atorvastatin reduces inflammation

platelet activity and incidence of MACE in patients with stable angina who had accepted the long-term statins therapy．