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纸质出版:2011
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陈瑞,陈功,陈荣昌,陈新.慢性阻塞性肺疾病患者劳力性呼吸困难与动态肺过度充气的关系[J].陆军军医大学学报(原第三军医大学学报),2011,33(18):1977-1979.
Chen Rui,Chen Gong,Chen Rongchang,Chen Xin.Correlation between exertional dyspnea and dynamic hyperinflation in patients with chronic obstructive pulmonary diseases[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(18):1977-1979.
陈瑞,陈功,陈荣昌,陈新.慢性阻塞性肺疾病患者劳力性呼吸困难与动态肺过度充气的关系[J].陆军军医大学学报(原第三军医大学学报),2011,33(18):1977-1979. DOI:
Chen Rui,Chen Gong,Chen Rongchang,Chen Xin.Correlation between exertional dyspnea and dynamic hyperinflation in patients with chronic obstructive pulmonary diseases[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(18):1977-1979. DOI:
目的 探讨慢性阻塞性肺疾病(chronic obstructive pulmonary diseases
COPD)患者在高强度恒定功率运动中呼吸困难的产生与动态肺过度充气的关系。 方法 对34例稳定期COPD患者和10例健康人进行常规肺通气功能、弥散功能、肺容量和症状限制递增功率心肺运动测试。以症状限制递增功率心肺运动测试获得的最大运动功率的2/3作为运动功率进行高强度恒定功率运动试验,在静息状态和运动过程中每隔1分钟记录受试者Borg呼吸困难评分、潮式呼吸-流速容积(TBFV)曲线和深吸气量(inspiratory capacity,IC)。 结果 COPD组在高强度恒定功率运动高峰时,IC[(1.56±0.29)L]较静息状态[(2.07±0.38)L]显著下降(t=-5.642,P0.01),ΔBorg与ΔIC呈显著负相关关系(r=-0.59
P0.01)。在运动高峰时COPD组平均呼气流速和呼气时间显著低于对照组。 结论 动态肺过度充气可能是COPD患者在高强度恒定功率运动中呼吸困难产生的主要原因之一;平均呼气流速下降和呼气时间缩短可能是COPD患者动态肺过度充气产生的原因。
Objective To study the correlation between exertional dyspnea and dynamic hyperinflation in patients with chronic obstructive pulmonary diseases (COPD). Methods Routine lung ventilation function
diffusing function
lung volume and symptom-limited progressive cycle ergometer exercise were tested in 34 stable COPD patients and 10 healthy controls. Two-thirds of their symptom-limited peak work rate was used to conduct high-intensity CWRE test. Borg dyspnea score
TBFV curve and inspiratory capability (IC) were detected every 1 min at rest and exercise. Results The IC was significantly lower in COPD patients at peak exercise than at rest (1.56±0.29 L vs 2.07±0.38 L
t=-5.642,P0.01). The ΔBorg was negatively correlated with the ΔIC in COPD patients (r=-0.59
P0.01). The mean expiratory flow and time were significantly lower in COPD patients than in healthy controls at peak exercise time (P0.05). Conclusion Dynamic hyperinflation is one of the important factors for dyspnea in stable COPD patients during high-intensity CWRE exercise. The decreased mean expiratory flow and time may be the reason for dynamic hyperinflation in COPD patients during exercise.
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