Objective       To evaluate the left ventricular longitudinal systolic function of children with Kawasaki disease in acute and chronic phase by quantitative tissue velocity imaging (QTVI) and tissue tracking imaging (TTI).      Methods       From April 2000 to September 2010

sixty-eight patients of our hospital were enrolled

whose average age was 5.94±3.02 years

including 30 patients with Kawasaki disease in acute phase (acute phase group)

18 patients with Kawasaki disease in chronic phase (chronic phase group) and 20 normal children (control group). The peak systolic velocities (Vs) and peak systolic velocities (Ds) in lateral

inferior

anterior and posterior wall of left ventricle and in anteroseptal and posteroseptal wall of interventricular septum were measured using QTVI and TTI.      Results       The average Vs of the acute phase group was significantly lower than those of the chronic phase group and the control group in mitral annulus

basal and middle segments (P＜0.05). The average Vs of the chronic phase group was significantly lower than that of the control group in mitral annulus and middle segments (P＜0.05)

but not in basal segment (P0.05). The average Ds of the acute phase group was significantly lower than those of the chronic phase group and the control group in mitral annulus

basal and middle segments (P＜0.05). The average Ds of the chronic phase group was significantly lower than that of the control group in mitral annulus and basal segments (P＜0.05)

but not in middle segment (P0.05).      Conclusion       QTVI combined with TTI can be applied to detect dysfunction of regional left ventricular myocardium contraction in acute and chronic phase of Kawasaki disease.