Objective      To study the correlation between single nucleotide polymorphism of human complement factor H gene (CFH) rs1061170 and coronary heart disease.      Methods      A total of 243 patients including 175 patients with coronary heart disease and 68 patients as controls who were admitted to the cardiology of Daping Hospital from Oct 2008 to Jun 2009 were enrolled. Fluorescence quantitative PCR was applied to detect the polymorphic genotype of CFH gene rs1061170 in the 243 patients. Frequency distribution of CFH gene was analyzed in CHD patients and control individuals. The clinical metabolic parameters of subgroups with different genotypes were compared.      Results      The frequency distributions TT

TC and CC genotypes of CFH gene rs1061107 in the CHD group and the control group were 87.4%

12.6% and 0 and 94.1%

5.9% and 0

respectively. The difference between the two groups was not significant (Chi square=2.293

OR=2.301

95%CI=0.762-6.943

P0.05). The frequency of T allele in the CHD group and the control group was 85.3% and 97.05%

respectively

and the difference was not significant (Chi square=2.164

OR=2.213

95%CI=0.748-6.546

P0.05). The SBP

DBP

BUN and Cr of CHD patients with TC genotype were significantly higher than those of the CHD patients with TT genotype (P0.05).      Conclusion      Polymorphism of CFH gene rs1061170 may not correlated with the incidence of coronary heart disease in the Han population of Chongqing.