Objective      To analyze the relationship between fetal congenital heart disease (CHD) and chromosome abnormalities in order to elevate the prenatal diagnosis accuracy for CHD.        Methods      Clinical data of 28 056 pregnant women with a mean age of 27.48±4.35 and a mean pregnancy period of 28.65±5.12 weeks in our out-patient department during Jan 2006 to Dec 2010 were enrolled in this study. Those fetus with CHD by ultrasonic cardiography further underwent chromosome examination. Gross anatomy was performed on the aborted fetuses

and the results were analyzes with those of ultrasonogram and chromosome karyotypes.       Results      Ultrasonic cardiography indicated that there were 592 fetuses with CHD in this group of pregnant women. In our valid follow-up

there were 79 aborted fetuses with identified CHD by gross anatomy. Among the 38 cases receiving chromosome examination

17 cases were with chromosome abnormality. Trisomy 21 was found in 3 cases

trisomy 18 in 7 cases

Klinefelter syndrome in 1 case

triploid in 1 case

sex reversal in 1 case

45

X/46

46

X

r(X) in 1 case

and little Y in 5 cases.       Conclusion      Prenatal chromosome examination should be carried out in the fetus with ultrasonography-diagnosed complex CHD or CHD combined with other organ abnormalities in order to elevate prenatal detection and avoid the birth of fetus with chromosome abnormalities.