Objective      To investigate the effect of Pseudomonas aeruginosa (PA) pulmonary infection on the treatment and prognosis of patients in respiratory intensive care unit (RICU).      Methods      A retrospective case-control study was conducted on 21 patients with PA infections (PA infection group) and 42 patients with non-PA infection (control group). The patients’ clinical indices including sex

age

smoking history

underlying disease

pathogenic bacteria distribution

drug sensitive test result

hospitalization time

hospitalization expense

invasive operation and prognosis were analyzed respectively.      Results      The resistance rate of PA to Imipenem accounted for 71.4% in PA infection group. The incidences of endotracheal intubation

tracheostomy and invasive mechanical ventilation of the PA infection group were obviously higher than those of the control group (P0.01). As compared with the control group

patients of the PA infection group had longer hospitalization time

higher hospitalization expenses and lower improvement rate (P0.01).      Conclusion      Invasive mechanical ventilation is a risk factor for patients complicated with PA pulmonary infection in RICU.