Objective      To explore the expression of trefoil factor family 2 (TFF2) in gastric mucosa

serum and gastric juice in rats with gastric ulcer.      Methods      Rat gastric ulcer was inflicted by injection acetic acid to submucosa of paries anterior gastricus. The expressions of TFF2 in gastric mucosa of gastric ulcer group (GU)

normal saline group (NS) and normal group (N) were detected by immunohistochemical (IHC) staining. Its level in serum and gastric juice were detected by ELISA.     Results     The results of IHC and ELISA showed that the expression of TFF2 peptide was significantly increased in the early stage of healing of gastric ulcer (1

2

4 and 6 d). The immunohistochemical expression of TFF2 reached the peak on the day 6 in GU (24.50±5.68)

and its immunostaining was more stronger near the muscularis mucosa

which mainly located in the cytoplasm of parietal cells and mucous neck cells. The serum level of TFF2 was the highest on the day 2 （338.62±58.72 pmol/L） and that of gastric juice was on day 1 （5 021.65±291.69 pmol/L）

respectively

and both of them were significantly higher than those of normal saline group and normal group.     Conclusion     TFF2 is strongly expressed in the mucosa

serum and gastric juice in early stage of gastric ulcer healing. TFF2 might be involved in the healing of gastric mucosa through different expression ways.