Objective    To study the significance of occurrence

development and lymphatic metastasis of non-small cell lung carcinoma (NSCLC) by observing the expression level of zinc finger protein 266 (ZNF266) in NSCLC tissue with differential biological behaviors.     Methods    Expression levels of ZNF266 in 30   samples of primary NSCLC tissue without lymphatic metastasis and its adjacent normal tissue

and in 30 samples of primary NSCLC tissue with lymphatic metastasis

were measured with the 3-step SABC immunohistochemistry method.     Results    The positive expression rate of ZNF266 was significantly higher in primary NSCLC tissue samples than in its adjacent normal tissue samples（40% vs 7%

P0.01)

and in primary NSCLC tissue samples with lymphatic metastasis than in those without lymphatic metastasis (67% vs 40%

P0.05).The expression level of ZNF266 was significantly higher in primary NSCLC tissue samples with lymphatic metastasis than in those without lymphatic metastasis (93% vs 67%

P0.05).     Conclusion    ZNF266 gene is involved in the occurrence

development and lymphatic metastasis of NSCLC.