Objective     To investigate the effect of atorvastatin on the expressions of angiotensin Ⅱ-induced atrial myocytes connective tissue growth factor （CTGF）and Connexin 43 (Cx43) in atrial myocytes.     Methods     A total of 18 Wistar rats of both genders

weighing from 35 to 40 g and aging about 1 week were used for culturing primary atrial myocytes and identification. The cells were divided into 6 groups

normal control

AngⅡ(1 μmol/L)

AngⅡ+dimethyl sulfoxide (DMSO) and AngⅡ+ atorvastatin (0.1

1.0 and 10 μmol/L). In 72 h after treatment

mRNA expressions of CTGF

transforming growth factor-β1（TGF-β1）and Gx43 were measured by reverse transcription-polymerase chain reaction (RT-PCR).     Results    Compared with normal control group

expressions of CTGF

TGF-β1 and Gx43 were increased significantly in AngⅡ group (P0.05)

but atorvastatin reversed those changes in a dose-dependent manner (P0.05). However

DMSO had no such effect as a solvent（P0.05).     Conclusion     Atorvastatin maybe attenuate atrial fribosis by inhibiting the increase of mRNA expression of CTGF induced by AngⅡ

reverse the remodeling of connexin by downregulating mRNA expression of Cx43

and thus reduce the incidence rate of atrial fibrillation.