Objective    To study the clinical effects of Xuefuzhuyu decoction (a traditional Chinese medicine) combined with aripiprazole in the treatment of schizophrenic patients with antipsychotic-induced amenorrhea.     Methods     Sixty-seven schizophrenic patients with antipsychotic-induced amenorrhea were randomly divided into group A (33 patients) treated with Xuefuzhuyu decoction combined with aripiprazole

and group B (34 patients) treated with aripiprazole alone. The treatment course was 3 months. The concentrations of prolactin (PRL) in serum were measured at the beginning of the study and at the end of each month

and the clinical effects on antipsychotic-induced amenorrhea were compared. The clinical effects on schizophrenosis were assessed using Positive and Negative Syndrome Scale (PANSS) at the beginning and the end of the study.     Results    The differences between PRL concentrations (base line and at the end of the 1st

2nd

and 3rd months) of group A (113.88±40.84 μg/L

43.59±17.35 μg/L

16.88±8.42 μg/L and 15.53±6.28 μg/L) and group B (111.94±39.27 μg/L

42.15±17.27 μg/L

17.59±7.22 μg/L and 16.26±5.46 μg/L) had no statistical significance (t=0.196-0.600

P=0.845-0.550). The curative rate of antipsychotic-induced amenorrhea of group A (100.00%) was not significantly different from that of group B (97.06%) (Chi square=0.956

P=0.328). The total PANSS score of group A (45.69±13.28) was significantly lower than that of group B (54.03±18.52) at the end of the 3-month study (t=-2.091

P=0.040).     Conclusion    In the treatment of schizophrenic patients with antipsychotic-induced amenorrhea

Xuefuzhuyu decoction combined with aripiprazole can help to restore menstruation and improve the curative effect on schizophrenia.