标准化免疫治疗对哮喘儿童屋尘螨特异性IgG<sub>4</sub>和肺功能的影响

韩洁; 黄英; 王模奎

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标准化免疫治疗对哮喘儿童屋尘螨特异性IgG₄和肺功能的影响

论著 | 更新时间：2026-01-09

- 标准化免疫治疗对哮喘儿童屋尘螨特异性IgG₄和肺功能的影响
- Influence of specific immunotherapy on Dermatophagoides pteronyssinus-specific IgG₄ and pulmonary function in children suffering from allergic asthma
- 陆军军医大学学报 2011年33卷第6期页码：618-620
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  中图分类号： R725.622.5;R457.2;R332
- 纸质出版：2011
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韩洁,黄英,王模奎.标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(06):618-620.

　Han Jie,Huang Ying,Wang Mokui.Influence of specific immunotherapy on Dermatophagoides pteronyssinus-specific IgG4 and pulmonary function in children suffering from allergic asthma[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(06):618-620.
韩洁,黄英,王模奎.标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(06):618-620. DOI：

　Han Jie,Huang Ying,Wang Mokui.Influence of specific immunotherapy on Dermatophagoides pteronyssinus-specific IgG4 and pulmonary function in children suffering from allergic asthma[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(06):618-620. DOI：

摘要

目的探讨标准化屋尘螨变应原制剂免疫治疗儿童哮喘，对其肺功能、气道反应性及血清屋尘螨特异性IgG

、血清屋尘螨特异性IgE的影响。方法选择31例轻-中度屋尘螨过敏性哮喘儿童，给予标准化屋尘螨变应原制剂治疗，疗程25周，检测治疗前后肺功能指标FEV1和PEF占预计值的百分比，PC20、血清屋尘螨特异性IgG

和屋尘螨特异性IgE水平。结果标准化特异性免疫治疗前后哮喘患儿肺功能FEV1和PEF占预计值的百分比分别为：治疗前（97.87±23.44）%、（99.95±29.52）%，治疗后（114.81±17.65）%、（116.51±19.52）%；治疗前后PC20值分别为（1.49±2.75）、（7.31±7.02）mg/ml；血清屋尘螨特异性IgG

水平治疗前为271.4 AU/ml（436.6 AU/ml）、治疗后为2 450.5 AU/ml（2 771.95 AU/ml）；血清屋尘螨特异性IgE水平治疗前为87.14 AU/ml(70.26 AU/ml)、治疗后为100.00 AU/ml(59.25 AU/ml）。除了特异性IgE在治疗前后无显著变化(P0.05)外，其余各项指标在治疗后均有显著上升(P0.01)。结论特异性免疫治疗对变应性哮喘患儿的肺功能有明显的改善，血清屋尘螨特异性IgG

的升高在哮喘的免疫治疗中发挥了重要的保护作用。

Abstract

Objective To explore the influence of specific Dermatophagoides pteronyssinus allergen preparation on pulmonary function

airway responsiveness

serum Dermatophagoides pteronyssinus-specific IgG

and serum Dermatophagoides pteronyssinus-specific IgE of children suffering from allergic asthma. Methods Thirty-one children with mil

d-to-moderate dermatophagoides pteronyssinus allergic asthma were treated with specific immunotherapy using Dermatophagoides pteronyssinus allergen preparation for 25 weeks. The pulmonary function indexes

including percentages of FEV1 and PEF to their forecast values and PC20

as well as serum Dermatophagoides pteronyssinus-specific IgG

level and serum Dermatophagoides pteronyssinus-specific IgE level were determined before and after the specific immunotherapy. Results After the specific immunotherapy

the percentages of FEV1 and PEF compared with their forecast values increased from (97.87±23.44)% and (99.95±29.52)% to (114.81±17.65)% and (116.51±19.52)%

respectively (P0.01). PC20 increased from 1.49±2.75 mg/ml to 7.31±7.02 mg/ml (P0.01). Serum Dermatophagoides pteronyssinus-specific IgG

level and serum Dermatophagoides pteronyssinus-specific IgE level changed from 271.4 AU/ml (436.6 AU/ml) and 87.14 AU/ml (70.26 AU/ml) to 2 450.5 AU/ml (2 771.95 AU/ml) and 100.00 AU/ml (59.25 AU/ml)

respectively

indicating insignificant difference of specific IgE level (P0.05) but significant increase of specific IgG

level (P0.01). Conclusion Specific immunotherapy can significantly improve the pulmonary function of children suffering from allergic asthma. The increase of serum Dermatophagoides pteronyssinus-specific IgG

plays an important role in immunotherapy of asthma.

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标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响

Influence of specific immunotherapy on Dermatophagoides pteronyssinus-specific IgG4 and pulmonary function in children suffering from allergic asthma

DOI：

摘要

Abstract

关键词

Keywords

references

标准化免疫治疗对哮喘儿童屋尘螨特异性IgG₄和肺功能的影响

Influence of specific immunotherapy on Dermatophagoides pteronyssinus-specific IgG₄ and pulmonary function in children suffering from allergic asthma