Objective    To investigate the problems and difficulties in prevention and control of schistosomiasis by investigating the status quo of schistosomiasis prevention and control ability of health professionals in Three Gorges Dam Reservoir area of Chongqing (China) and its influence factors.    Methods    General data about health professionals in Wanzhou district

Kaixian County and Yunyang County were collected with questionnaires

qualitative interviews

and multi-stage stratified cluster sampling method

including their age

experience and knowledge in schistosomiasis prevention and control

training

difficulties and problems encountered in their work

as well as their suggestions

which were analyzed by chi-square test and theme framework analysis

respectively

using the MAXqda software.    Results    Of the 180 health professionals invested with questionnaires and 25 with interviews

93.33% graduated from college or had a lower education

73.33% had not any experience in schistosomiasis prevention and control

47.78% were quite poor in basic knowledge about schistosomiasis prevention and control

and 75.56% did not receive any training in the past year. It was difficult to conduct serological examination in migrants and local inhabitants. The number of health professionals was not enough to monitoring oncomelania. Health education was limited to spread pamphlets about the sources of infection. The financial support from government was limited with no cooperation between government departments.    Conclusion   The knowledge about schistosomiasis prevention and control is poor in health professionals of Three Gorges Reservoir area of Chongqing. Health professionals lack of training. Monitoring of sources infection and oncomelania as well as health education have begun. More financial support from government is demanded. The ability of health professionals should be strengthened. Health professionals shall be sent to the epidemic areas to get experience. Health education should be conducted and comprehensive measures should be taken against schistosomiasis spread.