Objective    To investigate the value of CT perfusion imaging in quantitative monitoring on microcirculation hemodynamics

differences between tumor and normal tissues

differences between mass center and edge

and on tumour microvascular responses to anti-angiogenesis therapy.     Methods    Fifteen male New Zealand white rabbits were established to VX

2

tumor-bearing model. The animals were divided into 2 groups

anti-angiogenesis therapy (n=11

TNP-470

20 to 30 mg/kg)

and control (n=4). DEC-CT scanning (80 kV

120 mA

20 cm VOF) was performed at 1 week after tumor implantation

1 week after anti-angiogenesis therapy

and 2 week after antiangiogenesis therapy. Perfusion parameters

including blood flow (BF)

blood volume (BV)

mean transit time (MTT)

and permeability surface (PS) were calculated for tumor mass

tumor edge

tumor center and normal tissue.     Results    Significant differences of the average values were observed in BF

PS and MTT between tumor and normal tissue [149.32±30.99 vs 32.18±4.10 ml/(100 g·min)

28.24±5.15 vs 11.88±0.71 ml/(100 g·min)

2.79±0.66 vs 6.57±0.90 s

P0.05

]

. Difference was also seen between tumor edge [175.70±34.43 ml/(100 g·min)

32.43±6.52 ml/(100 g·min)

3.87±0.84 s

]

and tumor center [19.07±3.58 ml/(100 g·min)

18.75±2.10 ml/(100 g·min)

8.11±1.44 s

]

. The significant changes of BF

BV

PS

MTT were observed in the therapy group from 187.57 ml/(100 g·min)，5.21 ml/100 g，and 30.74 ml/(100 g·min)，3.87s respectively to 118.48 ml/(100 g·min)，4.21 ml/100 g，24.02 ml/(100 g·min)，and 4.27s in 2 weeks after anti-angiogenesis therapy

but not observed in control group [129.74 ml/(100 g·min)，3.22 ml/100 g，25.85 ml/(100 g·min)，and 3.68 s vs 362.33 ml/(100 g·min)，10.86 ml/100 g，39.31 ml/(100 g·min)，and 3.54 s

]

.     Conclusion    CT perfusion imaging can provide quantitative information on the changes in microcirculation hemodynamics for tumor

and it is a valuable tool for quantitative monitoring on tumour microvascular responses to

anti-angiogenesis therapy.