Objective To analyze the relationship of the different ovarian response and clinical outcome in

in vitro

fertilization - embryo transfer (IVF - ET) cycles. Methods A total of 414 cases of IVF - ET during 2008 to 2009 in our department were retrospectively analyzed. Poor responder was defined as ≤ 5 retrieved oocytes (

n

=79)

normal responder as retrieved oocytes 5 and ≤ 15 (

n

=239)

and high responder as retrieved oocytes 15 （

n

=96 ） . Correlat

ion of number of retrieved oocytes with clinical outcome

age

medicine

hormone level

fertilization ratio and the good embryo ratio was evaluated. Results Clinical pregnancy ratio in poor responders was significantly lesser than normal responders group and higher responder group (25 . 3%

vs

41.4% and 43.8%

P

0 . 05). The cancellation cycle ratio in poor responders group was significantly higher than that in the other groups (20.0%

vs

2.9% and 5.2%

P

0 . 05). The clinical outcomes was significantly correlated with ages

endometrium thickness at ET

retrieved oocyte numbers and the number of good embryo for ET (

r

=-0.145

0.150

0.141

and 0.215 respectively

P

0 . 01). The retrieved oocyte numbers was significantly correlated with age

E

2

and LH at HCG injection day

E

2

and P and P/E at ET day (

P

0 . 01

P

0 . 05). Conclusion The ovarian responders (the retrieved oocyte numbers) is tightly related with clinical outcomes

and the age is an important contribution factor on retrieved oocyte numbers. Pregnant rate may be improved by elevating ovarian response.