Objective    To study the pathological changes in liver lobe of Bama pigs after selective bile duct ablation with 5% hydrochloric acid as an as ablation reagent and cyanoacrylate as an embolization reagent.     Methods    A tube was placed in bile duct in swine left liver lobe and selective bile duct ablation was performed. Liver function

pathologic change in liver tissue and survival time of the animals were observed after operation.     Results    No death occurred after operation. The ALT

AST and ALP levels reached their peak in 3 d after operation and became normal in 7 d after operation. The collagen-stained area in center and border of target liver lobe was larger than normal (P0.05). The level of hydroxyproline was higher in target liver lobe than in normal liver lobe (P0.05).     Conclusion    Selective bile duct ablation with 5% hydrochloric acid and cyanoacrylate can lead to atrophy of target liver lobe in Bama swine.