幽门螺杆菌感染增强胃癌组织Runx3基因甲基化与患者生存的关系

赵永勋; 关泉林; 张兴旺; 赵鹏; 汪晓炜; 袁文臻; 曹农

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幽门螺杆菌感染增强胃癌组织Runx3基因甲基化与患者生存的关系

论著 | 更新时间：2026-01-09

- 幽门螺杆菌感染增强胃癌组织Runx3基因甲基化与患者生存的关系
- Correlation between H.pylori infection-increased Runx3 methylation in gastric cancer tissue and survival rate of gastric cancer patients
- 陆军军医大学学报 2010年32卷第13期页码：1429-1432
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  中图分类号： R735.2;R181.23;R730.4
- 纸质出版：2010
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赵永勋,关泉林,张兴旺,赵鹏,汪晓炜,袁文臻,曹农.幽门螺杆菌感染增强胃癌组织Runx3基因甲基化与患者生存的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1429-1432.

　Zhao Yongxun,Guan Quanlin,Zhang Xingwang,Zhao Peng,Wang Xiaowei,Yuan Wenzhen,Cao Nong.Correlation between H.pylori infection-increased Runx3 methylation in gastric cancer tissue and survival rate of gastric cancer patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1429-1432.
赵永勋,关泉林,张兴旺,赵鹏,汪晓炜,袁文臻,曹农.幽门螺杆菌感染增强胃癌组织Runx3基因甲基化与患者生存的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1429-1432. DOI：

　Zhao Yongxun,Guan Quanlin,Zhang Xingwang,Zhao Peng,Wang Xiaowei,Yuan Wenzhen,Cao Nong.Correlation between H.pylori infection-increased Runx3 methylation in gastric cancer tissue and survival rate of gastric cancer patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1429-1432. DOI：

摘要

目的研究胃癌Runx3基因甲基化和幽门螺杆菌（H.pylori）感染、临床病理特征及患者生存的关系。方法筛选我院肿瘤外科2004年6月至2005年12月86例病理确诊的原发性胃癌患者，男性52例，女性34例，平均年龄52（28～78）岁。20例正常对照选自同期我院消化内科门诊。用甲基化特异性PCR（MSP）法检测胃癌组织、癌旁组织及正常对照组织中Runx3基因甲基化状况；用快速尿素酶诊断法和Warthin-Starry染色法检测胃癌患者及对照组H.pylori感染状况；用Kaplan-Meier限乘法计算生存率；用Cox比例风险回归模型进行多因素生存分析。结果 ①胃癌组织Runx3甲基化率（65.1%，56/86）明显高于相应癌旁组织（8.1%，7/86）和正常对照组织（0/20）（P0.01）。②Runx3甲基化与组织分化(P=0.017)、浸润深度（P=0.004）及淋巴结转移(P=0.001)等显著相关。③H.pylori感染的胃癌组织Runx3甲基化率较未感染的胃癌组织高（P=0.003）。④Kaplan-Meier生存曲线经Log-rank检验发现Runx3甲基化与生存相关（P0.01）。⑤多因素生存分析显示浸润深度、Runx3甲基化是胃癌的独立预后因素（P0.05）。结论胃癌Runx3甲基化与肿瘤进展和转移有关，H.pylori感染增加Runx3甲基化，Runx3甲基化是胃癌的独立预后因素。

Abstract

Objective To study the correlation between Runx3 methylation in gastric cancer tissue

H.pylori infection

clinicopathologic features and survival rate of gastric cancer patients. Methods Eighty-six patients with primary gastric cancer (52 males and 34 females) at the age of 28-78 years (mean 52 years)

admitted to Department of Oncology Surgery from June 2004 to December 2005

were selected as an experimental group

and 20 patients admitted to Department of Gastroenterology during the same period were selected as a control group. Runx3 methylation was detected by methylation specific (MSP) PCR in gastric cancer tissue

its adjacent and normal gastric tissues. H.pylori infection was detected by fast urea enzyme test with Warthin-Starry staining in experimental and control groups. Survival rate was calculated by Kaplan-Meier survival curves. Multivariate survival analysis was performed with Cox proportional hazard regression model. Results The Runx3 methylated rate was significantly higher in gastric cancer tissue (65.1%，56/86) than in adjacent gastric tissue (8.1%，7/86) and normal gastric tissue （0/20）(P0.01). The Runx3 methylation was significantly correlated with tissue differentiation

depth of invasion

and lymph node metastasis (P=0.05). The Runx3 methylation rate was higher in gastric cancer tissue infected with H.pylori than in those not infected with H.pylori (P=0.003). Kaplan-Meier survival curves and Log rank test showed that Runx3 methylation was correlated with survival rate of gastric cancer patients (P0.01). Multivariate survival analysis revealed that depth of invasion and Runx3 methylation were the independent prognostic factors for gastric cancer. Conclusion Runx3 methylation is correlated with the development and metastasis of gastric cancer. H.pylori infection increases Runx3 methylation

and Runx3 methylation is an independent prognostic factor for gastric cancer.

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