Objective    To investigate the expressions of lipid metabolism-related genes in breast invasive ductal carcinoma and adjacent non-cancerous tissues

and evaluate their roles in the occurrence of breast invasive ductal carcinoma.     Methods    Experimental samples were derived from our previous population study on breast cancer. Breast cancer tissues and adjacent non-cancerous tissues were spontaneously collected from 30 invasive ductal carcinoma patients. The expressions of fatty acid synthase (FAS)

cyclooxygenase-2 (Cox-2)

5-lipoxygenase (5-LOX) and peroxisome proliferator-activated receptor γ (PPAR-γ) mRNA were detected by RT-PCR.     Results    Expressions of FAS

Cox-2

and 5-LOX in breast cancer tissues were significantly higher than those in adjacent tissues (FAS: 3.265±0.913 vs 1.300±0.712

P0.01; Cox-2 and 5-LOX: 2.449±1.333 vs 1.027±0.596

P0.05; 2.766±1.193 vs 1.159±0.520

P0.05). There was no significant difference of PPAR-γ expression between the 2 groups (2.771±1.313 vs 2.235±1.383

P0.05).     Conclusion    Higher expressions of FAS

Cox-2

and 5-LOX are positively correlated with the occurrence of breast invasive ductal carcinoma.