Objective   To investigate the expressions and correlation of monocarboxylate transporter-1 (MCT1) and CD147 in human gliomas

and analyzee the relationship between their expressions and prognosis.    Methods   Immunohistochemistry SP methods were applied to detect the expressions of MCT1 and CD147 in 28 cases of low grade gliomas and 32 cases high grade gliomas. Their expression level and correlation were analyzed statistically. Prospective cohorts were set to acquire follow-up data. Kaplan-Meier curve and Cox multi-factor model were used to analyze patients’ prognosis.    Results   Both CD147 and MCT1 had strong expressions in human gliomas. The positive expression rate of MCT1 and CD147 （93.8% and 90.6%） and the strong positive expression rate (73.3% and 72.4%) in high grade gliomas were significantly enhanced compared with that of low grade gliomas (positive expression rate: 46.4% and 50%

strong positive expression rate: 30.8% and 35.7%

P0.01

P0.05) and their expression had positive correlation (r=0.671

P0.05). The Kaplan-Meier curve related with the expression of MCT1 and CD147 were statistically different（P=0.021 and P=0.001）

CD147 significantly interfered with patients’ prognosis in COX analysis（P=0.017）.    Conclusion   The expressions of CD147 and MCT1

especially CD147

are closely related to the malignant degree of gliomas. They may be useful reference factors to evaluate prognosis of human gliomas and potential targets for therapy.