26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析

郑志鹏; 周杰

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26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析

论著 | 更新时间：2026-01-09

- 26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析
- Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases
- 陆军军医大学学报 2010年32卷第10期页码：1106-1108
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  中图分类号： R372;R617;R657.3
- 纸质出版：2010
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郑志鹏,周杰.26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1106-1108.

　Zheng Zhipeng,Zhou Jie.Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1106-1108.
郑志鹏,周杰.26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1106-1108. DOI：

　Zheng Zhipeng,Zhou Jie.Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1106-1108. DOI：

摘要

目的探讨肝移植术后早期真菌感染的流行病学特点及耐药特性。方法回顾性分析本院2004年8月至2009年1月所施行的118例肝移植患者中真菌感染病例，通过真菌培养鉴定及药敏试验分析真菌感染特点。结果 26例发生真菌感染，患病率为22.0%。感染部位主要发生在呼吸道（75.5%），共分离出49株真菌，以白色念珠菌为主（57.1%），曲霉菌、光滑念珠菌、热带念珠菌、近平滑念珠菌、克柔念珠菌的检出率分别为18.4%、10.2%、6.1%、4.1%、4.1%。药敏试验显示药物敏感率从高到低依次为伏立康唑、伊曲康唑、两性霉素B、氟胞嘧啶、氟康唑，分别为92.0%、90.0%、75.5%、73.5%、55.1%。结论肝移植术后真菌感染主要是白色念珠菌，氟康唑的总体敏感性较低，临床上应加强肝移植术后患者真菌的鉴定和耐药监测，合理选用抗真菌药物。

Abstract

Objective To investigate the epidemiology and drug resistance associated with fungal infection during early postoperative period after liver transplantation in the purpose of prevention and treatment. Methods A total of 118 cases of liver transplantation admitted from April 2004 to January 2009 in Nanfang Hospital were studied retrospectively

and the fungal infection and drug resistance were identified. Results Fungal infections occurred in 26 cases (22.0%). Totally there were 49 fungi strains isolated

of which mainly Candida albicans (57.1%)

followed by Aspergillus (18.4%)

Smooth Candida (10.2%)

Candida tropicalis (6.1%)

Candida parapsilosis (4.1%)

and Candida krusei (4.1%). The sensitive rate of voriconazole

itraconazole

amphotericin B

5-fluorouracil

fluconazole were 92.0%

90.0%

75.5%

73.5%

and 55.1% respectively. Conclusion Because of the change of fungi strains and the increase of drug resistance

it’s important to identify the fungi and drug resistance for the purpose of prophylaxis and treatments.

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