Objective   To investigate the effects of four ingredients for dispersing pathogenic wind (FIDPW) granules on thymus

spleen and proliferation of their T and B lymphocytes in mice with allergic contact dermatitis (ACD).    Methods   Sixty mice were randomly divided into normal group

ACD group

hydrocortisone (HC) group and high

medium

and low FIDPW dose groups

10 mice in each group. Auricle swelling

spleen and thymus indexes

mitogen-induced proliferation of spleen T and B lymphocytes were determined.    Results   The auricle swelling was lower in HC

low

medium and high FIDPW dose groups than in ACD group  (P0.05). The effect of high and medium FIDPW dose was better than that of low FIDPW dose on auricle swelling (P0.05) with no difference in HC

high and medium FIDPW dose groups (P0.05). The thymus and spleen indexes were significantly lower in HC

low

medium and high FIDPW dose groups than in ACD group  (P0.05). The effect of high and medium FIDPW dose was better than that of low FIDPW dose on thymus and spleen indexes with no difference between high FIDPW dose and HC groups (P0.05). A significant difference was found in mitogen-induced proliferation of spleen T and B lymphocytes in ACD

HC

low

medium and high FIDPW dose groups  (P0.05). The effect of medium and high FIDPW dose was better than that of low FIDPW dose on mitogen-induced proliferation of spleen T and B lymphocytes (P0.05) with no difference between low and high FIDPW dose and HC groups (P0.05).    Conclusion   FIDPW granules can prevent and treat ACD in mice by regulating the function of T and B lymphocytes.