Objective   To observe the expression of insulin receptor mRNA in skeletal muscle and the change of oxidative stress in diabetic rats at different intensity training.    Methods   Sprague-Dawley rats were divided into group A（control group），group B（non-exercise group），group C（low-intensity exercise group)，group D（moderate-intensity exercise group) and group E（high-intensity exercise group)

6 rats in each group. A diabetic rat model was induced by injecting streptozotocin（STZ）for 4 weeks after high lipid and glucose breeding. Rats were trained for 6 weeks on a treadmill. Serum glucose and insulin，insulin resistance index（HOMA-IR），activities of SOD and GSH-Px，and MDA were detected before and after training. Expression levels of InsR mRNA in skeletal muscle were measured by RT-PCR.     Results   The InsR receptor mRNA expression level in three exercise groups at different intensities was 0.55±0.05

0.53±0.04

and 0.41±0.05

respectively

and was significantly higher in low and moderate intensity exercise groups than in group B (P0.05). Six weeks after training，the activity of SOD was significantly higher in low and moderate intensity exercise groups（P0.01）

the activity of GSH-Px was significantly higher in high-intensity exercise group（P0.05）while the MDA level was lower in low and moderate intensity exercise groups than in group B（P0.01）.    Conclusion   The InsR receptor mRNA expression is different in skeletal muscle of diabetic rats at different intensity training，which may be related to the inhibitory effect of oxidative stress on insulin signal transduction.