Objective    To observe the expression of programmed death receptor-ligand 1 (PD-L1) in human cervical carcinoma and its correlation with tumor T cell infiltration.     Methods    Expression of PD-L1 and PD-1 was detected in 5 normal cervical tissue samples，7 high-level cervical intraepithelial neoplasia (CI

N Ⅱ-Ⅲ) tissue samples and 67 cervical carcinoma tissue samples

respectively

with immunohistochemistry staining. The number of tumor infiltrating CD4

+

T and CD8

+

T cells was counted with immunofluorescent staining. Apoptotic tumor infiltration lymphocytes were examined by TUNEL assay.     Results    PD-L1 was not expressed in normal cervical epithelium and negatively or weakly expressed in cancerous cervical epithelium. PD-L1 was expressed in 70% (47/67) of cervical carcinoma tissue samples.  PD-1 was expressed in partial tumor infiltrating lymphocytes (P0.01). The expression level of PD-L1 was slightly lower in superficial invasive cervical carcinoma tissue samples than in deep invasive carcinoma tissue samples. The number of CD8

+

T cells was significantly decreased in patients with positive PD-L1.The expression of PD-L1 was negatively correlated with the number of tumor infiltrating CD8

+

T cells (r=-0.82，P0.01) but not with the number of CD4

+

T cells (r=-0.05，P 0.05). Apoptosis occurred in partial tumor infiltrating lymphocytes of cervical carcinoma tissue samples.     Conclusion    PD-L1 is expressed in cervical carcinoma cells. The expression of PD-L1 is correlated with the reduced number of tumor infiltrating CD8

+

T cells but not with the number of CD4

+

T cells. PD-L1 expression in tumor cells may play role in apoptosis of tumor infiltrating lymphocytes.