Objective　To explore the relationship between angiogenesis and ischemic neurological deficit repair through exogenous interventions

and investigate optimal intervention routes for angiogenesis in cerebral ischemia rats. 　Methods　Totally 240 SD rats were randomly divided into sham operation group

ischemic control group

ischemia and vascular endothelial growth factor (VEGF) group [1 653.3 ng/(g·d)

i.p.

for 10 d

]

ischemia and endothelial progenitor cell transplantation (EPCs) grou

p (2×10

10

/L

10 μl)

ischemia and anti-VEGF monoclonal antibody group [3 mg/(kg·d)

i.p.

for 10 d

]

. Cerebral microvessel density

somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) and behavior were observed in 1

3

7

14

30 and 60 d after injury. 　Results　New blood vessel density of ischemia and VEGF group

ischemia and EPCs group were significantly higher than ischemic control group in all time points besides 1 d after injury (P0.05). On the contrary

ischemia and anti-VEGF group was lower than ischemic control group in posterior 5 time points (P0.05). SEP and MEP of ischemic control group and ischemia and VEGF group

ischemia and EPCs group

ischemic and anti-VEGF group had statistically significant differences from ischemic control group after 7 d (P0.05). Behavior was significantly different among all groups after 3 d (P0.05). 　Conclusion　Exogenous intervention in cerebral ischemia rats with ischemic angiogenesis can affect repair of neurological deficits. And VEGF therapy through multiple injections and a single transplanted endothelial progenitor cells can receive similar results.