星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响

张晓东; 杨天德; 李洪

您当前的位置：

首页 >

文章列表页 >

星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响

论著 | 更新时间：2026-01-09

- 星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响
- Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass
- 陆军军医大学学报 2010年32卷第10期页码：1028-1030
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R392.3;R614.4;R654.1
- 纸质出版：2010
- 稿件说明：
移动端阅览
张晓东,杨天德,李洪.星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1028-1030.

　Zhang Xiaodong,Yang Tiande,Li Hong.Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1028-1030.
张晓东,杨天德,李洪.星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1028-1030. DOI：

　Zhang Xiaodong,Yang Tiande,Li Hong.Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1028-1030. DOI：

摘要

目的探讨星状神经节阻滞后体外循环手术后患者炎症反应的影响。方法把我院心外科20例需进行二尖瓣置换的手术患者进行随机分组，分为对照组、星状神经节阻滞组（n=10）。对照组不予处理，星状神经节阻滞组予以1％利多卡因进行星状神经节阻滞。分别于术前20 min，麻醉后20 min，手术20 min，体外循环20 min，体外循环后20 min取血标本，检测皮质醇、IL-1β、IL-6、TNF-α的血浆浓度。结果皮质醇在体外循环后20 min时，星状神经节阻滞组（353.09±129.34）与对照组（486.84±152.20)有明显差异（P0.05）。IL-1β、IL-6、TNF-α都有逐渐上升的趋势；星状神经节阻滞组[IL-1β（0.15±0.06）、IL-6（293.50±54.41）、TNF-α（2.37±0.52）]在体外循环后20 min血浆浓度明显低于对照组[IL-1β （0.22±0.08）ng/ml，IL-6 (341.17±43.06) ng/ml， TNF-α(2.92±0.57）ng/ml，P0.05]。结论星状神经节阻滞可有效地减轻体外循环引起的炎症反应，其机制有待进一步探讨。

Abstract

Objective To study the effect of stellate ganglion blocking (SGB) during cardiopulmonary bypass (CPB) on inflammatory reaction. Methods Twenty patients undergoing mitral valve replacement were randomly allocated to 2 matched groups

control group and SGB group (n=10). The control group only received conventional anesthesia

while the SGB group was blocked with 1% lidocaine in addition before the operation for SBG. Blood glucose (BG)

Cortisol (Col)

IL-1β

IL-6 and TNF-α in the venous blood samples were detected in following 5 time points

20 min before anesthesia

20 min after anesthesia

20 min after operation

20 min afer the start of CPB and 20 min after the end of CPB. Results Col level of the control group (353.09±129.34 ng/ml) was significantly higher than that of the SGB group (486.84±152.20 ng/ml) in 20 min after the end of CPB (P0.05). Serum levels of IL-1β

IL-6 and TNF-α had a trend of increasing. However

the serum levels of IL-1β [(0.15±0.06) ng/ml

IL-6 (293.50±54.41) pg/ml

TNF-α (2.37±0.52) ng/ml] in the SGB group were lower than those of the control group [IL-1β (0.22±0.08) ng/ml

IL-6(341.17±43.06) pg/ml

and TNF-α (2.92±0.57) ng/ml] in 20 min after the end of CPB (P0.05). Conclusion SGB can relieve inflammatory reaction induced by CPB.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

小儿体外循环围术期炎症因子释放规律及机制探讨

乌司他丁对严重烧伤大鼠血清中致炎因子的影响及意义

反复缺血预适应对心肌缺血再灌注损伤大鼠TLR4和致炎细胞因子TNF-α、IL-1β的影响

P物质刺激下脊髓星形胶质细胞活化中磷酸化P38丝裂素活化蛋白激酶和c-fos的表达及作用

P物质对脊髓星形胶质细胞活化和炎性因子IL-1β、TNF-α分泌的影响