兔VX2肿瘤超声造影灌注定量参数与肿瘤组织周细胞变化

黄泽君; 李锐; 张莹; 陈朝晖; 袁曼丽; 杨正春

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兔VX2肿瘤超声造影灌注定量参数与肿瘤组织周细胞变化

论著 | 更新时间：2026-01-09

- 兔VX2肿瘤超声造影灌注定量参数与肿瘤组织周细胞变化
- Quantitative perfusion parameters of VX2 tumor at ultrasonography and change of pericytes in tumor tissue of rabbits
- 陆军军医大学学报 2010年32卷第4期页码：331-333
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  中图分类号： R445.1;R73-354;R730.41
- 纸质出版：2010
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黄泽君,李锐,张莹,陈朝晖,袁曼丽,杨正春.兔VX2肿瘤超声造影灌注定量参数与肿瘤组织周细胞变化[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):331-333.

　Huang Zejun,Li Rui,Zhang Ying,Chen Zhaohui,Yuan Manli,Yang Zhengchun.Quantitative perfusion parameters of VX2 tumor at ultrasonography and change of pericytes in tumor tissue of rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(04):331-333.
黄泽君,李锐,张莹,陈朝晖,袁曼丽,杨正春.兔VX2肿瘤超声造影灌注定量参数与肿瘤组织周细胞变化[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):331-333. DOI：

　Huang Zejun,Li Rui,Zhang Ying,Chen Zhaohui,Yuan Manli,Yang Zhengchun.Quantitative perfusion parameters of VX2 tumor at ultrasonography and change of pericytes in tumor tissue of rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(04):331-333. DOI：

摘要

目的探讨兔VX2肿瘤超声造影定量新生血管血流灌注参数与肿瘤组织周细胞变化的关系。方法选用VX2肿瘤肌肉模型兔10只，应用超声造影连续脉冲对比(comparative pulse serial， CPS)技术及ACQ定量分析软件测定肿瘤血管血流灌注各参数值和峰值强度比率(rate of peak index

RPI)

并与肿瘤组织标记周细胞的免疫组化染色检测的微血管密度(micro vascular density

MVD)和周细胞数(pericytes number

PN)对照

进行相关性分析。结果肿瘤组织造影血流灌注参数峰值强度（peak intensity，PI）为(15.29±4.14)dB，RPI为(2.95±1.26)dB/s；肿瘤组织标记周细胞的MVD为(17.75±7.60)，PN为(26.10±10.59)；肿瘤组织造影血流灌注参数PI与MVD和PN显著正相关（r值分别为0.866、0.857，P0.01），RPI与MVD和PN显著正相关（r值分别为0.647、0.648，P0.01），而到达时间（arrival time， AT）、达峰时间（time-to-peak，TTP）与MVD、PN无相关性。结论超声造影血流灌注参数PI和RPI 可以间接反映肿瘤血管生成中周细胞的数量、分布、密度以及微血管密度等变化。

Abstract

Objective To study the correlation between perfusion parameters of new blood vessels in VX2 tumor at ultrasonography and change of pericytes in tumor tissue of rabbits. Methods Ten rabbits with implanted VX2 tumor cells were enrolled in this study. Comparative pulse serial (CPS) technique and ACQ software were used to detect the ratio between perfusion parameters of tumor vessels and rate of peak index (RPI). Micro vascular density (MVD) was detected in tumor tissues stained with immunohistochemistry and compared with that in pericytes

and their correlation was analyzed. Results The mean PI and RPI in perfused tumor tissue were 15.29±4.14 dB/s and 2.95±1.26 dB/s

respectively. The mean MVD and the number of pericytes in tumor tissue were 17.75±7.60 and 26.10±10.59

respectively. The PI and RPI were positively correlated with MVD and pericytes. Conclusion Ultrasonic PI and RPI can indirectly reflect the changes of pericytes during the angiogenesis in tumors.

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