模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响

孔耀; 刘鲁川; 周霞; 刘福玉; 杨苏平; 张海元

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模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响

论著 | 更新时间：2026-01-09

- 模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响
- Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis
- 陆军军医大学学报 2010年32卷第4期页码：324-326
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  中图分类号： R339.54;R446.112;R781.4
- 纸质出版：2010
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孔耀,刘鲁川,周霞,刘福玉,杨苏平,张海元.模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):324-326.

　Kong Yao,Liu Luchuan,Zhou Xia,Liu Fuyu,Yang Suping,Zhang Haiyuan.Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(04):324-326.
孔耀,刘鲁川,周霞,刘福玉,杨苏平,张海元.模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):324-326. DOI：

　Kong Yao,Liu Luchuan,Zhou Xia,Liu Fuyu,Yang Suping,Zhang Haiyuan.Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(04):324-326. DOI：

摘要

目的研究常氧与缺氧条件下慢性牙周炎大鼠血清中基质金属蛋白酶2（matrix metalloproteinase-2

MMP-2）的表达变化，探讨MMP-2与高原牙周病的关系。方法模拟高原缺氧建立大鼠慢性牙周炎模型，采用ELISA法测定正常对照组、常氧牙周炎组、缺氧对照组、缺氧牙周炎组大鼠血清中MMP-2表达。结果正常对照组、常氧牙周炎组、缺氧对照组、缺氧牙周炎组血清中MMP-2浓度分别为(92.00±21.78)、(118.09±25.01)、(102.03±21.30)、(159.19±34.13) ng/ml，常氧牙周炎组与正常对照组、缺氧牙周炎组与缺氧对照组、缺氧对照组与正常对照组、缺氧牙周炎组与常氧牙周炎组比较均有统计学意义（P0.01）。其中缺氧牙周炎组血清中MMP-2浓度升高最为显著(P0.01)。结论缺氧上调血清中MMP-2的表达，进而促进大鼠牙周组织的破坏。

Abstract

Objective To study the change of matrix metalloproteinase-2 (MMP-2) expression in serum of rats with chronic periodontitis under normal oxygen or hypoxia conditions and the correlation between MMP-2 and high altitude periodontitis. Methods A chronic periodontitis model of rat was established by simulating high altitude hypoxia. Rats were divided into normal control (NC) group

normal oxygen periodontitis group (P

)

hypoxia control group（H）

and hypoxia periodontitis group (P

）. Expression of MMP-2 in serum of rats was detected by ELISA. Results The MMP-2 level in N

and P

groups was 92.00±21.78

118.09±25.01

102.03±21.30

and 159.19±34.13 ng/ml

respectively (P0.01). The serum MMP-2 level was significantly higher in P

group than in other groups. Conclusion Hypoxia up-regulates MMP-2 expression in serum and promotes destruction of periodontal tissue in rats

suggesting that MMP-2 participates in destruction of periodontal tissue during hypoxia periodontitis

which may be related with the recurrence and development of high altitude periodontal diseases.

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