Objective   To investigate the risk factors of postmenopausal osteoporosis (PMOP) in Chongqing region

and provide the theoretical basis for osteoporosis prevention and treatment.    Methods   A hospital-based case-control study was conducted and standardized questionnaire was applied in this project. All patients were informed of the purpose of this study and signed an informed consent form. The protocol and consent form were approved by the Ethics Committee of Third Military Medical University. Non-conditional logistic model was used to estimate the association between risk factors and PMOP.   Results   After adjustment for some potential confounding factors

multivariate non-conditional logistic regression analysis indicated that family history of hip fracture (OR=8.567

95%CI 3.463 to 12.620)

  lower body mass index (OR=3.081

95%CI 1.344 to 5.632)

and parities (OR=2.539

95%CI 1.263 to 4.175) were significantly positive correlated with the incidence of PMOP. However

frequently exercise (OR=0.276

95%CI 0.152 to 0.730)

tea drinking (OR=0.354

95%CI 0.209 to 0.764) and older at menopause (OR=0.621

95%CI 0.327 to 0.942) were significantly negative correlated with it.   Conclusion   Family history of hip fracture

  lower body mass index and higher parities are the risk factors of PMOP in Chongqing region. Besides

frequent exercise

tea drinking and proper endogenous estrogen level are the protective factors.